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The Effect of Cilostazol on Glucose Tolerance and Insulin Resistance in a Rat Model of Non-insulin Dependent Diabetes Mellitus
The Korean Journal of Internal Medicine ; : 87-92, 2001.
Article Dans Anglais | WPRIM | ID: wpr-219319
ABSTRACT

BACKGROUND:

It has been reported that many peripheral vasodilating drugs might improve insulin resistance. Cilostazol, a antithrombotic agent, increases peripheral blood flow in non-insulin dependent diabetic patients. The effect of cilostazol treatment on insulin resistance in streptozotocin (STZ)-induced non-insulin dependent diabetic Wistar rats was examined.

METHODS:

About a half of two-day old neonate siblings were injected intraperitoneally with STZ and maintained for six months, at which time they were compared with age-matched control rats for intraperitoneal glucose tolerance test (IPGTT) and for glucose infusion rate (GINF) in a euglycemic hyperinsulinemic glucose-clamp study. After that, these studies were also performed after feeding rat chow containing cilostazol (100 mg/kg/day) to rats with STZ-induced non-insulin dependent diabetes mellitus for four-weeks and compared with those of age-matched control rats.

RESULTS:

In the intraperitoneal glucose tolerance test studies, plasma glucose levels of STZ-induced non-insulin dependent diabetic rats were significantly higher and plasma insulin levels significantly lower than those of age-matched control rats in the age of six months. Glucose infusion rate was lower in STZ-induced non-insulin dependent diabetic rats than those of age-matched control rats. However, after a four-week cilostazol treatment, glucose infusion rate of STZ-induced non-insulin dependent diabetic rats was not significantly different from that of control rats.

CONCLUSION:

These findings suggested that cilostazol may improve insulin resistance in STZ-induced non-insulin dependent diabetic rats.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Valeurs de référence / Tétrazoles / Vasodilatateurs / Glycémie / Insulinorésistance / Étude comparative / Probabilité / Sensibilité et spécificité / Rat Wistar / Streptozocine Type d'étude: Etude diagnostique / Étude pronostique Limites du sujet: Animaux langue: Anglais Texte intégral: The Korean Journal of Internal Medicine Année: 2001 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Valeurs de référence / Tétrazoles / Vasodilatateurs / Glycémie / Insulinorésistance / Étude comparative / Probabilité / Sensibilité et spécificité / Rat Wistar / Streptozocine Type d'étude: Etude diagnostique / Étude pronostique Limites du sujet: Animaux langue: Anglais Texte intégral: The Korean Journal of Internal Medicine Année: 2001 Type: Article