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A case of severe hypophosphatemia related to adefovir dipivoxil treatment in a patient with liver cirrhosis related to hepatitis B virus / 대한간학회지
The Korean Journal of Hepatology ; : 381-386, 2008.
Article Dans Coréen | WPRIM | ID: wpr-219564
ABSTRACT
Adefovir dipivoxyl (ADV) effectively suppresses hepatitis B virus (HBV) replication but exhibits nephrotoxicity with severe hypophosphatemia when administered at a high dosage. This is the first report of severe hypophosphatemic osteomalacia induced by ADV at 10 mg/day. A 42-year-old man with HBV-related chronic liver disease presented with generalized bone pain, especially in the left ankle. He had been taking ADV for more than 1.5 years following a clinical breakthrough due to lamivudine-resistant HBV. Aggravating severe hypophosphatemia and elevated serum alkaline phosphatase levels with high bone fraction had been noted after 6 months of ADV therapy. Bone densitometry, simple bone X-rays, and a whole-body bone scan demonstrated osteoporosis and multiple areas with hot uptake, especially in the left ankle. All the image findings and symptoms improved after correcting the hypophosphatemia.
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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Antiviraux / Acides phosphoreux / ADN viral / Adénine / Tomodensitométrie / Absorptiométrie photonique / Densité osseuse / Virus de l'hépatite B / Hypophosphatémie / Lamivudine Limites du sujet: Adulte / Humains / Mâle langue: Coréen Texte intégral: The Korean Journal of Hepatology Année: 2008 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Antiviraux / Acides phosphoreux / ADN viral / Adénine / Tomodensitométrie / Absorptiométrie photonique / Densité osseuse / Virus de l'hépatite B / Hypophosphatémie / Lamivudine Limites du sujet: Adulte / Humains / Mâle langue: Coréen Texte intégral: The Korean Journal of Hepatology Année: 2008 Type: Article