Lipoprotein-Associated Phospholipase A2 Is Related to Plaque Stability and Is a Potential Biomarker for Acute Coronary Syndrome
Yonsei Medical Journal
; : 1507-1515, 2014.
Article
Dans En
| WPRIM
| ID: wpr-221612
Responsable en Bibliothèque :
WPRO
ABSTRACT
PURPOSE: Plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) binds to low-density lipoprotein. The levels of Lp-PLA2 reflect the plaque burden, and are upregulated in acute coronary syndrome (ACS). We investigated the diagnostic value of Lp-PLA2 levels and found that it might be a potential biomarker for ACS. MATERIALS AND METHODS: We classified 226 study participants into three groups: patients without significant stenosis (control group), patients with significant stenosis with stable angina (SA group), and patients with ACS (ACS group). RESULTS: Lp-PLA2 and high-sensitivity C-reactive protein (hs-CRP) levels were significantly greater in the ACS group than in the SA group (p=0.044 and p=0.029, respectively). Multivariate logistic regression analysis revealed that Lp-PLA2 levels are significantly associated with ACS (odds ratio=1.047, p=0.013). The addition of Lp-PLA2 to the ACS model significantly increased the global chi2 value over traditional risk factors (28.14 to 35.602, p=0.006). The area under the receiver operating characteristic curve for Lp-PLA2 was 0.624 (p=0.004). The addition of Lp-PLA2 level to serum hs-CRP concentration yielded an integrated discrimination improvement of 0.0368 (p=0.0093, standard error: 0.0142) and improved the ability to diagnose ACS. CONCLUSION: Lp-PLA2 levels are related to plaque stability and might be a diagnostic biomarker for ACS.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Protéine C-réactive
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Marqueurs biologiques
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Modèles logistiques
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Analyse multifactorielle
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Facteurs de risque
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Courbe ROC
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Coronarographie
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1-Alkyl-2-acetylglycerophosphocholine esterase
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Syndrome coronarien aigu
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Plaque d'athérosclérose
Type d'étude:
Etiology_studies
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Prognostic_studies
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Risk_factors_studies
Limites du sujet:
Aged
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Aged80
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Female
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Humans
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Male
langue:
En
Texte intégral:
Yonsei Medical Journal
Année:
2014
Type:
Article