Autophagy Activity in Pulmonary Metastatic Tumor Tissues from Colorectal Cancer: A Pilot Study
Yonsei Medical Journal
;
: 1484-1488, 2014.
Article
Dans Anglais
| WPRIM
| ID: wpr-221615
ABSTRACT
PURPOSE:
Autophagy has been reported to be involved in treatment failure in tumor. We aimed to evaluate autophagy activity in tumor tissue and compare them between the recurrence and non-recurrence groups. MATERIALS ANDMETHODS:
We analyzed expressions of autophagy-related proteins in tumor tissues which were obtained from pulmonary metastases of colorectal cancer patients by Western blot. We also analyzed autophagosomes by transmission electron microscopy.RESULTS:
Tumor tissues from recurrence group showed increased levels of LC3B-II, decreased levels of p62/SQSTM1, and also a marked accumulation of autophagosomes compared with tissues from non-recurrence group.CONCLUSION:
The present study suggests that autophagy may be associated with treatment failure of metastatic colorectal cancer.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Autophagie
/
Tumeurs colorectales
/
Protéines
/
Marqueurs biologiques tumoraux
/
Projets pilotes
/
Technique de Western
/
Études rétrospectives
/
Échec thérapeutique
/
Protéines adaptatrices de la transduction du signal
/
Microscopie électronique à transmission
Type d'étude:
Étude observationnelle
Limites du sujet:
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Yonsei Medical Journal
Année:
2014
Type:
Article
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