Localization of transforming growth factor beta1 in airway mucosa of toluene diisocyanate-induced asthma / 천식및알레르기
Journal of Asthma, Allergy and Clinical Immunology
;
: 500-507, 2001.
Article
Dans Coréen
| WPRIM
| ID: wpr-221668
ABSTRACT
BACKGROUND AND OBJECTIVE:
There have been some reports on the expression of TGF beta-an anti-inflammatory and fibrosing cytokine in airway mucosa of asthmatics. However, the ex- pression of TGF beta1 in bronchial mucosa of TDI-induced asthma is not known. The aim of this study was to observe immunolocalization of TGF beta1 in airway mucosa of TDI-induced asthma.METHODS:
TGF beta1 expressions were compared using immunohistochemistry in bronchial muco- sa from 22 subjects with TDI-induced asthma (group I 10 newly diagnosed, group II 12 subjects with persistent asthma symptoms for more than 4 years after diagnosis), and 8 non- asthmatics undergoing pneumonectomy from lung tumor. The distribution and intensity of expression were analyzed by two observers in four areas of bronchial tissue-epithelium(EP), vascular endothelium(VE), smooth muscle(SM), and mucous glands(MG).RESULTS:
Positive rates of TGF beta1 expression for groups I and II in the four areas were as follows; EP (50% vs 100%, p0.05). Grades of TGF beta1 expression of EP, VE, and SM were significantly higher in group II than in group I(p0.05, respectively).CONCLUSION:
TGF beta1 expressions of EP, VE, SM and MG were noted in airway mucosa of TDI-induced asthma and expressions of EP, VE, and SM were more intense and frequent in patients with persistent asthma symptoms.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pneumonectomie
/
Asthme
/
Toluène
/
Immunohistochimie
/
Facteurs de croissance transformants
/
Facteur de croissance transformant bêta-1
/
Poumon
/
Muqueuse
Limites du sujet:
Humains
langue:
Coréen
Texte intégral:
Journal of Asthma, Allergy and Clinical Immunology
Année:
2001
Type:
Article
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