The Clinical Significance of Antibody Screening Test Including Di(a+) Panel Cell in Asian-Mongoloid Populations
Journal of Korean Medical Science
; : 669-672, 2003.
Article
de En
| WPRIM
| ID: wpr-221858
Bibliothèque responsable:
WPRO
ABSTRACT
The Di(a) antigen is well known as one of the antigens with low incidence among Caucasians; however, it has been discovered with a relatively higher incidence among Mongoloid populations. Thus, it has been speculated that the incidence of unexpected antibody against the Di(a) antigen might be relatively higher among these populations. Hemolytic transfusion reactions (HTRs) and hemolytic disease of the newborns (HDNs) caused by anti-Di(a) have been reported sporadically. However, there has been no prospective study on the incidence of anti-Di(a) in Mongoloid populations particularly. The authors conducted a series of antibody screening tests on 11,219 Korean individuals for 25 months, by using three kinds of screening cells including Di(a) cell. Anti-Di(a) was detected in 8 patients, seven of whom had a history of transfusions or were multigravida. The incidence of anti-Di(a) measured in this study was higher than expected, ranked third among unexpected antibodies identified during the period of the study, so it is strongly recommended that the Di(a+) panel cell must be incorporated into antibody screening test for safer transfusion in Asian-Mongoloid populations.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Banques de sang
/
Antigènes de groupe sanguin
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Transfusion sanguine
/
Groupage sanguin et épreuve de compatibilité croisée
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Techniques immunologiques
/
Asiatiques
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Érythrocytes
/
Corée
/
Production d'anticorps
Type d'étude:
Diagnostic_studies
/
Observational_studies
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Prognostic_studies
/
Screening_studies
Limites du sujet:
Adult
/
Female
/
Humans
/
Male
Pays comme sujet:
Asia
langue:
En
Texte intégral:
Journal of Korean Medical Science
Année:
2003
Type:
Article