Mast Cells and Lipid Mediators
Journal of Bacteriology and Virology
;
: 47-51, 2016.
Article
Dans Anglais
| WPRIM
| ID: wpr-221987
ABSTRACT
Human mast cells are potent effector cells in host defense mechanisms of innate and acquired immunity, including inflammatory diseases such as asthma and atherosclerosis. Mast cells originate from pluripotent hematopoietic progenitors in the bone marrow. Activation of mast cells by different stimuli triggers the release of a large range of mediators, including de novo synthesized eicosanoids which are highly biologically active lipid mediators. For the generation of lipid mediators, cytoplasmic lipid droplets have been shown to function as a major intracellular pool of arachidonic acid, the precursor for eicosanoids biosynthesis. The article summarizes current knowledge on mast cell biosynthesis of lipid mediator and the role in inflammation.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Asthme
/
Moelle osseuse
/
Éicosanoïdes
/
Acide arachidonique
/
Cytoplasme
/
Mécanismes de défense
/
Athérosclérose
/
Immunité acquise
/
Inflammation
/
Mastocytes
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Journal of Bacteriology and Virology
Année:
2016
Type:
Article
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