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Extracorporeal Therapy as a Treatment Method in Patients with Acute Ethylene Glycol Poisoning
Journal of the Korean Society of Emergency Medicine ; : 109-116, 2017.
Article Dans Coréen | WPRIM | ID: wpr-222531
ABSTRACT

PURPOSE:

Extracorporeal treatment has been used increasingly to treat patients with acute ethylene glycol poisoning. We analyzed all patients with acute poisoning of ethylene glycol during a recent 10-year period to provide clinical recommendations for adequate application of continuous renal replacement therapy for these patients.

METHODS:

A retrospective chart review study was conducted for patients whose final diagnosis were “toxic effects of glycols or other alcohols,” between October 2006 and September 2016. The basal characteristics of patients, suspected amount of ingestion, intention of poisoning, concomitant alcohol ingestion, mental state at admission, time from exposure to admission, chief complaint, length of hospital stay, method of treatments, laboratory results including acute kidney injury and urine oxalate crystal, as well as treatment results were examined.

RESULTS:

A total number of 14 patients were included in this study. Nine patients (64.3%) underwent continuous renal replacement therapy; 5 patients (35.7%) underwent ethanol mono-therapy. Between the antidote therapy group and the extracorporeal treatment group, there was a significant difference in the levels of plasma bicarbonate, chloride, anion gap, pH, and base excess in arterial blood gas analysis, as well as the calculated osmolar gap. One patient expired due to multi-organ failure, while the others recovered completely.

CONCLUSION:

Continuous renal replacement therapy was most frequently chosen as a treatment method in patients with acute ethylene glycol poisoning. Further research regarding indication of continuous renal replacement therapy and combing therapy with other treatment will be necessary to determine the best treatment method.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Plasma sanguin / Intoxication / Équilibre acido-basique / Gazométrie sanguine / Études rétrospectives / Traitement substitutif de l'insuffisance rénale / Crêtes et barbillon / Éthylène glycol / Intention / Diagnostic Type d'étude: Etude diagnostique / Guide de pratique / Étude observationnelle Limites du sujet: Animaux / Humains langue: Coréen Texte intégral: Journal of the Korean Society of Emergency Medicine Année: 2017 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Plasma sanguin / Intoxication / Équilibre acido-basique / Gazométrie sanguine / Études rétrospectives / Traitement substitutif de l'insuffisance rénale / Crêtes et barbillon / Éthylène glycol / Intention / Diagnostic Type d'étude: Etude diagnostique / Guide de pratique / Étude observationnelle Limites du sujet: Animaux / Humains langue: Coréen Texte intégral: Journal of the Korean Society of Emergency Medicine Année: 2017 Type: Article