A case of leptomeningeal metastasis from adenocarcinoma of the lung improved by treatment with Gefitinib / 대한내과학회지
Korean Journal of Medicine
;
: 198-202, 2008.
Article
Dans Coréen
| WPRIM
| ID: wpr-222776
ABSTRACT
Leptomeningeal metastasis occurs in approximately 1% of patients with non-small cell lung cancer and this is an extremely serious complication. Without treatment, the median survival of patients is 4~6 weeks. The treatment options currently available are limited and achieve only modest results. Gefitinib was recently approved for the treatment of advanced/refractory non-small cell lung cancer. In addition, there have been case reports showing activity of gefitinib against brain metastasis in non-small cell lung cancer patients. However, there is limited data on the ability of gefitinib to cross the blood-brain barrier. We report the case of a patient with leptomeningeal metastasis from adenocarcinoma of the lung that had a dramatic response to gefitinib treatment.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Quinazolines
/
Encéphale
/
Barrière hémato-encéphalique
/
Adénocarcinome
/
Carcinome pulmonaire non à petites cellules
/
Poumon
/
Métastase tumorale
Limites du sujet:
Humains
langue:
Coréen
Texte intégral:
Korean Journal of Medicine
Année:
2008
Type:
Article
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