A case of myeloid neoplasm with the PDGFRB rearrangement and eosinophilia / 대한내과학회지
Korean Journal of Medicine
;
: 386-390, 2010.
Article
Dans Coréen
| WPRIM
| ID: wpr-224540
ABSTRACT
Myeloid neoplasm with the platelet-derived growth factor receptor beta (PDGFRB) rearrangement is a myeloproliferative neoplasm. Patients with this disease often have prominent eosinophilia or monocytosis and the presence of t(5;12)(q31~33;p12) or a variant translocation with expression of an ETV6-PDGFRB fusion gene or the PDGFRB rearrangement. We report an 82-year-old woman with a myeloid neoplasm, with the PDGFRB rearrangement, who presented with a dry cough, eosinophilia and thrombocytosis. The chromosome study of the bone marrow showed 46,XX,ins(1;5)(q22;q33q13.3), and fluorescence in situ hybridization (FISH) analysis revealed rearrangement of the PDGFRB gene. The patient was successfully treated with low-dose imatinib.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pipérazines
/
Pyrimidines
/
Thrombocytose
/
Benzamides
/
Moelle osseuse
/
Récepteurs aux facteurs de croissance dérivés des plaquettes
/
Hybridation in situ
/
Toux
/
Récepteur au PDGF bêta
/
Éosinophilie
Limites du sujet:
Adulte très âgé
/
Aged80
/
Femelle
/
Humains
langue:
Coréen
Texte intégral:
Korean Journal of Medicine
Année:
2010
Type:
Article
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