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Apigenin and Wogonin Regulate Epidermal Growth Factor Receptor Signaling Pathway Involved in MUC5AC Mucin Gene Expression and Production from Cultured Airway Epithelial Cells / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases ; : 120-126, 2014.
Article Dans Anglais | WPRIM | ID: wpr-224804
ABSTRACT

BACKGROUND:

We investigated whether wogonin and apigenin significantly affect the epidermal growth factor receptor (EGFR) signaling pathway involved in MUC5AC mucin gene expression, and production from cultured airway epithelial cells; this was based on our previous report that apigenin and wogonin suppressed MUC5AC mucin gene expression and production from human airway epithelial cells.

METHODS:

Confluent NCI-H292 cells were pretreated with wogonin or apigenin for 15 minutes or 24 hours and then stimulated with epidermal growth factor (EGF) for 24 hours or the indicated periods.

RESULTS:

We found that incubation of NCI-H292 cells with wogonin or apigenin inhibited the phosphorylation of EGFR. The downstream signals of EGFR such as phosphorylation of MEK1/2 and ERK1/2 were also inhibited by wogonin or apigenin.

CONCLUSION:

The results suggest that wogonin and apigenin inhibits EGFR signaling pathway, which may explain how they inhibit MUC5AC mucin gene expression and production induced by EGF.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Phosphorylation / Expression des gènes / Apigénine / Facteur de croissance épidermique / Cellules épithéliales / Récepteurs ErbB / Mucines Limites du sujet: Humains langue: Anglais Texte intégral: Tuberculosis and Respiratory Diseases Année: 2014 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Phosphorylation / Expression des gènes / Apigénine / Facteur de croissance épidermique / Cellules épithéliales / Récepteurs ErbB / Mucines Limites du sujet: Humains langue: Anglais Texte intégral: Tuberculosis and Respiratory Diseases Année: 2014 Type: Article