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Genetic Syndromes associated with Congenital Heart Disease
Korean Circulation Journal ; : 357-361, 2015.
Article Dans Anglais | WPRIM | ID: wpr-225173
ABSTRACT
Recent research has demonstrated that genetic alterations or variations contribute considerably to the development of congenital heart disease. Many kinds of genetic tests are commercially available, and more are currently under development. Congenital heart disease is frequently accompanied by genetic syndromes showing both cardiac and extra-cardiac anomalies. Congenital heart disease is the leading cause of birth defects, and is an important cause of morbidity and mortality during infancy and childhood. This review introduces common genetic syndromes showing various types of congenital heart disease, including Down syndrome, Turner syndrome, 22q11 deletion syndrome, Williams syndrome, and Noonan syndrome. Although surgical techniques and perioperative care have improved substantially, patients with genetic syndromes may be at an increased risk of death or major complications associated with surgery. Therefore, risk management based on an accurate genetic diagnosis is necessary in order to effectively plan the surgical and medical management and follow-up for these patients. In addition, multidisciplinary approaches and care for the combined extra-cardiac anomalies may help to reduce mortality and morbidity accompanied with congenital heart disease.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Gestion du risque / Malformations / Syndrome de Turner / Études de suivi / Mortalité / Syndrome de Down / Syndrome de Williams / Soins périopératoires / Diagnostic / Syndrome de délétion 22q11 Type d'étude: Etude diagnostique / Etude d'étiologie / Étude observationnelle / Étude pronostique Limites du sujet: Humains langue: Anglais Texte intégral: Korean Circulation Journal Année: 2015 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Gestion du risque / Malformations / Syndrome de Turner / Études de suivi / Mortalité / Syndrome de Down / Syndrome de Williams / Soins périopératoires / Diagnostic / Syndrome de délétion 22q11 Type d'étude: Etude diagnostique / Etude d'étiologie / Étude observationnelle / Étude pronostique Limites du sujet: Humains langue: Anglais Texte intégral: Korean Circulation Journal Année: 2015 Type: Article