A Study of Antibiotic Susceptibility of Staphylococcus aureus in Bacterial Skin Infections / 대한피부과학회지

ABSTRACT

BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) is an important nosocomial pathogen. It can also cause community-acquired infection. However, there are few reports on MRSA in community-acquired infections. OBJECTIVE: To evaluate the prevalence and antibiotic susceptibility of Staphylococcus aureus (S. aureus) in community-acquired bacterial skin infections. METHODS: Bacterial cultures and antimicrobial susceptibility tests were performed on out-patients with bacterial skin infection from January 2004 to October 2005. RESULTS: Of 252 pyoderma cases, bacteria were cultured from 145 (57.5%) cases. Among them, S. aureus was isolated from 85 (33.7%) patients. Eight (9.4%) S. aureus isolates were MRSA. The others were coagulase-negative Streptococcus (10.3%), Streptococcus (5.6%) and gram-negative bacilli (12.3%). The resistant rates of S. aureus against antibiotics were as follows penicilin 97.6%, tetracycline 29.7%, gentamycin 23.5%, tobramycin 16.2%, fusidic acid 13.5%, oxacillin 9.4%, erythromycin 8.1%, aberkacin 5%, ciprofloxacin 4.7%, rifampin 2.7%, clindamycin 2.4%, trimethoprim/sulfameth-oxazole 2.4%, amoxicillin/clavulanic acid 0%, teicoplanin 0% and vancomycin 0%. The effective antibiotics for the treatment of MRSA were amoxicillin/clavulanic acid (0%), teicoplanin (0%) and vancomycin (0%). CONCLUSION: S. aureus was the most predominent pathogen in community-acquired pyoderma, and was sensitive to oxacillin, erythromycin, aberkacin, ciprofloxacin, rifampin, clindamycin, trimethoprim/sulfametho-xazole, amoxicillin/clavulanic acid, teicoplanin and vancomycin. Among these, amoxicillin/clavulanic acid, teicoplanin and vancomycin were also effective in the treatment of MRSA.