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Comparison of Cardiovascular Risk Profiles and Graft Function between Cyclosporin A-based and Tacrolimus-based Immunosuppression in Renal Transplant Recipients / 대한신장학회지
Korean Journal of Nephrology ; : 610-618, 2007.
Article Dans Coréen | WPRIM | ID: wpr-226304
ABSTRACT

PURPOSE:

Tacrolimus (TAC) may be less unfavorable than cyclosporin A (CsA) on cardiovascular morbidity and mortality in renal transplant recipients, but well controlled studies are insufficient.

METHODS:

In this prospective randomized controlled study, fifty seven consecutive renal transplant recipients were treated with CsA-based (CsA, MMF and steroid, CsA group n=27) or TAC-based (TAC, MMF and steroid, TAC group n=30) immunosuppressive regimens by randomized ratio of 11. In the baseline (pre-operation), 1, 3, and 6 months after transplantation, several cardiovascular risk factors and graft function were evaluated.

RESULTS:

There were no significant differences in the renal function, glucose regulation, the incidence of acute rejection and post-transplant diabetes mellitus for the post-transplant 6 months between the two groups. The blood pressure of the CsA group was maintained higher than TAC group through 6 months after transplantation even though the number of antihypertensive drugs in the CsA group was significantly higher at 3 and 6 month after transplantation. The lipid profiles except oxidized LDL were similar, but oxidized LDL level was significantly higher for the post-transplant 6 months in the CsA group (p<0.05). There were no significant differences in levels of fibrinogen, PAI-I, t-PA, hs-CRP, homocysteine, spot urine TGF-beta a and beta ig-h3, but the uric acid level was significantly higher in the CsA group (p<0.05).

CONCLUSION:

This study demonstrates that TAC tends to have a beneficial effect on cardiovascular risk profiles, with regard to BP and atherogenic properties of serum lipids in early post-transplant period.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Transplantation / Acide urique / Pression sanguine / Fibrinogène / Système cardiovasculaire / Incidence / Études prospectives / Facteurs de risque / Mortalité / Facteur de croissance transformant bêta Type d'étude: Essai clinique contrôlé / Etude d'étiologie / Etude d'incidence / Étude observationnelle / Étude pronostique / Facteurs de risque langue: Coréen Texte intégral: Korean Journal of Nephrology Année: 2007 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Transplantation / Acide urique / Pression sanguine / Fibrinogène / Système cardiovasculaire / Incidence / Études prospectives / Facteurs de risque / Mortalité / Facteur de croissance transformant bêta Type d'étude: Essai clinique contrôlé / Etude d'étiologie / Etude d'incidence / Étude observationnelle / Étude pronostique / Facteurs de risque langue: Coréen Texte intégral: Korean Journal of Nephrology Année: 2007 Type: Article