Deletion of Rb1 gene in late osteosarcoma from survivor of unilateral retinoblastoma: a case report
Journal of Korean Medical Science
;
: 94-98, 1996.
Article
Dans Anglais
| WPRIM
| ID: wpr-226468
ABSTRACT
It has been well known that the survivors of retinoblastoma are prone to have osteosarcoma. But the secondary tumor usually occurs in bilateral, hereditary type of retinoblastoma. We report one case of osteosarcoma in a survivor of unilateral, sporadic retinoblastoma. A fourteen year old male presented with a painfully swollen distal forearm of 2 month duration. He had enucleated his left eye 10 years ago due to retinoblastoma with no other adjuvant therapy. We managed him with our conventional protocol and identified deletion of Rb gene from his pathological specimen by using the PCR-RFLP method. This result is unusual for unilateral nonhereditable retinoblastoma and may suggest gene level change even in sporadic cases. And Rb gene study may be helpful for unilateral, sporadic retinoblastoma patient in detecting the possibility of late osteosarcoma.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Rétinoblastome
/
Imagerie par résonance magnétique
/
Données de séquences moléculaires
/
Séquence nucléotidique
/
Ostéosarcome
/
Gènes du rétinoblastome
/
Délétion de gène
/
Survivants
/
Amorces ADN
Type d'étude:
Guide de pratique
Limites du sujet:
Adolescent
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Journal of Korean Medical Science
Année:
1996
Type:
Article
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