Is familial papillary thyroid microcarcinoma more aggressive than sporadic form?
Annals of Surgical Treatment and Research
;
: 129-135, 2017.
Article
Dans Anglais
| WPRIM
| ID: wpr-226737
ABSTRACT
PURPOSE:
With the increasing incidence of papillary thyroid microcarcinoma (PTMC), familial papillary thyroid microcarcinoma (FPTMC) is now recognized more frequently. However, the biological behavior of FPTMC is poorly understood. The aim of this study was to investigate the prevalence of FPTMC and its biological aggressiveness.METHODS:
Between March 2006 and July 2010, 2,414 patients underwent primary surgical therapy for PTMC and 149 (6.2%) were further classified as FPTMC. To determine the biological aggressiveness of FPTMC, we compared the clinicopathological features and prognosis between FPTMC and sporadic PTMC (SPTMC).RESULTS:
The male-to-female ratio was higher in FPTMC than in sporadic papillary thyroid microcarcinoma (SPTMC 14.5 vs. 17.2, P = 0.041). The central lymph node (LN) metastasis rate was significantly higher in FPTMC than in SPTMC (36.2% vs. 24.2%, P = 0.002). The local recurrence rate was also higher in FPTMC than in SPTMC (4.5% vs. 0.6%, P < 0.001). We identified familial occurrence in 6.2% of cases of PTMC. FPTMC is associated with a high rate of central LN metastasis and local recurrence.CONCLUSION:
These findings suggest that close follow-up can be beneficial in FPTMC patients to detect local recurrence.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pronostic
/
Récidive
/
Glande thyroide
/
Incidence
/
Prévalence
/
Études de suivi
/
Agressivité
/
Noeuds lymphatiques
/
Métastase tumorale
Type d'étude:
Etude d'incidence
/
Étude observationnelle
/
Étude de prévalence
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Annals of Surgical Treatment and Research
Année:
2017
Type:
Article
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