Physicians' preferences and perceptions regarding donor selection in allogeneic stem cell transplantation in Korea when a matched domestic donor is not available
Blood Research
;
: 31-36, 2017.
Article
Dans Anglais
| WPRIM
| ID: wpr-226885
ABSTRACT
BACKGROUND:
A number of alternative donor options exist for patients who fail to find domestic HLA-matched donors for allogeneic hematopoietic stem cell transplantation (allo-HSCT). We assessed physicians' perspectives on allo-HSCT donor selection when a matched domestic donor is not available.METHODS:
We administered a questionnaire survey to 55 hematologists (response rate 28%) who attended the annual spring conference of the Korean Society of Haematology in 2015. The questionnaire contained four clinical allo-HSCT scenarios and the respondents were asked to choose the most preferred donor among the given options.RESULTS:
In all four scenarios, the hematologists preferred a matched international donor over partially mismatched unrelated domestic or haplo-matched family donors. The numbers of hematologists who chose a matched international donor (HLA 8/8) in cases of acute myeloid leukemia, chronic myeloid leukemia, acute lymphoblastic leukemia, and aplastic anemia were 37 (67.3%), 41 (74.6%), 33 (60.0%), and 36 (65.5%), respectively. The important factors that affected donor selection included “expecting better clinical outcomes (40.5%)” and “lower risk of side effects (23.4%).” The majority of participants (80%) responded that allo-HSCT guidelines for donor selection customized for the Korean setting are necessary.CONCLUSION:
Although hematologists still prefer perfectly matched foreign donors when a fully matched domestic allo-HSCT donor is not available, we confirmed that there was variation in their responses. For evidence-based clinical practice, it is necessary to provide further comparative clinical evidence on allo-HSCT from haplo-matched family donors and fully matched unrelated international donors.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Cellules souches
/
Donneurs de tissus
/
Leucémie myéloïde chronique BCR-ABL positive
/
Leucémie aigüe myéloïde
/
Enquêtes et questionnaires
/
Transplantation de cellules souches hématopoïétiques
/
Transplantation de cellules souches
/
Sélection de donneurs
/
Leucémie-lymphome lymphoblastique à précurseurs B et T
/
Donneurs non apparentés
Type d'étude:
Guide de pratique
/
Recherche qualitative
Limites du sujet:
Humains
Pays comme sujet:
Asie
langue:
Anglais
Texte intégral:
Blood Research
Année:
2017
Type:
Article
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