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Cronobacter sakazakii Infection Induced Fatal Clinical Sequels Including Meningitis in Neonatal ICR Mice / 한국실험동물학회지
Laboratory Animal Research ; : 59-62, 2011.
Article Dans Anglais | WPRIM | ID: wpr-227292
ABSTRACT
Cronobacter sakazakii (C. sakazakii), formerly Enterobacter sakazakii, is an emerging pathogen associated with the ingestion of contaminated reconstituted formula that causes serious illnesses such as bacteremia, septicemia, necrotizing enterocolitis, meningitis and death in low-birth-weight preterm neonatal infants. The objective of this study was to develop an animal model for human neonatal C. sakazakii infections. We acquired timed-pregnant ICR mice and allowed them to give birth naturally. On postnatal day 3.5, each pup was administered orally a total dose of approximately 107 CFU C. sakazakii strain 3439. Mice were observed twice daily for morbidity and mortality. At postnatal day 10.5, the remaining pups were euthanized, and brain, liver, and cecum were excised and analyzed for the presence of C. sakazakii. C. sakazakii was isolated from cecum and other tissues in inoculated mice. In the tissues of C. sakazakii infected mice, meningitis and gliosis were detected in brain. In this study, we confirmed the neonatal ICR mice may be used a very effective animal model for human neonatal C. sakazakii infections.
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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Entorses et foulures / Encéphale / Caecum / Bactériémie / Sepsie / Entérocolite nécrosante / Modèles animaux / Parturition / Cronobacter sakazakii / Consommation alimentaire Limites du sujet: Animaux / Humains langue: Anglais Texte intégral: Laboratory Animal Research Année: 2011 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Entorses et foulures / Encéphale / Caecum / Bactériémie / Sepsie / Entérocolite nécrosante / Modèles animaux / Parturition / Cronobacter sakazakii / Consommation alimentaire Limites du sujet: Animaux / Humains langue: Anglais Texte intégral: Laboratory Animal Research Année: 2011 Type: Article