The Comparison of Antiemetic Effects of Metoclopramide, Granisetron and Ondansetron in Middle Ear Surgery / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 1036-1041, 2000.
Article
Dans Coréen
| WPRIM
| ID: wpr-228358
ABSTRACT
BACKGROUND:
Postoperative nausea and vomiting (PONV) is a distressing adverse effect of anesthesia. This study was designed to evaluate antiemetic effects of metoclopramide, ondansetron and granisetron in middle ear surgery.METHODS:
We compared the antiemetic activity of prophylactic administration of metoclopramide, ondansetron and granisetron in 103 patients undergoing middle ear surgery (tympanomastoidectomy and tympanoplasty). All Study drugs were given as a short intravenous infusion 30 minutes before the end of anesthesia. The incidence of PONV were assessed by direct questioning of patients at 6, 12, 24 and 48 hr after recovery from anesthesia.RESULTS:
For the first 6 hr recovery period after surgery, the percentages of emesis in patients were 46.7%, 16%, 12% and 16% in the control, metoclopramide, ondansetron and granisetron groups respectively. After 6 hr, the percentage of emesis in patients significantly decreased in the control, ondansetron and granisetron groups when compared with the first 6 hr, but in the metoclopramide group there was no changes after 6 hr.CONCLUSIONS:
The antiemetic drugs, metoclopramide, ondansetron and granisetron, were all effective in controling PONV in middle ear surgery.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Vomissement
/
Perfusions veineuses
/
Incidence
/
Ondansétron
/
Granisétron
/
Vomissements et nausées postopératoires
/
Oreille moyenne
/
Anesthésie
/
Métoclopramide
/
Antiémétiques
Type d'étude:
Etude d'incidence
/
Étude pronostique
Limites du sujet:
Humains
langue:
Coréen
Texte intégral:
Korean Journal of Anesthesiology
Année:
2000
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS