Effect of Tamoxifen in C6 Glioma Cells
Journal of Korean Neurosurgical Society
;
: 5-10, 1997.
Article
Dans Coréen
| WPRIM
| ID: wpr-228730
ABSTRACT
This work describes tamaoxifen, a nonsteroidal antiestrogen compound, which has been used extensively in the treatment of breast cancer on account of its efficacy and relatively low toxicity. It has been reported to inhibit glioma proliferation in all cell line tested, acting by a mechanism independent of estrogen receptor blockade. Tamoxifen causes cytotoxicity at higher concentration(>or=5 micrometer), as compared with control. Our results showed that this compound decreased the rate of cell proliferation in dose-dependent manner. Its treatment against the C6 glioma cells also resulted in enhancement of the antitumor effect. These data suggest that tamoxifen may serve as an useful agent in chemotherapy of glioma.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Tamoxifène
/
Tumeurs du sein
/
Lignée cellulaire
/
Modulateurs des récepteurs des oestrogènes
/
Prolifération cellulaire
/
Traitement médicamenteux
/
Oestrogènes
/
Gliome
langue:
Coréen
Texte intégral:
Journal of Korean Neurosurgical Society
Année:
1997
Type:
Article
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