A Direct Inhibitory Effect of Botulinum Toxin Type A on Antral Circular Muscle Contractility of Guinea Pig
Yonsei Medical Journal
;
: 968-973, 2012.
Article
Dans Anglais
| WPRIM
| ID: wpr-228774
ABSTRACT
PURPOSE:
Recent studies suggest new mechanisms of Botulinum toxin (BoNT) other than inhibiting acetylcholine (ACh) release from nerve terminals. The aim of this study was to determine whether other mechanisms for BoNT exist, so that it directly inhibits smooth muscle contraction. MATERIALS ANDMETHODS:
Guinea pig antral muscle strips were studied in vitro after 2 hours of exposure to Botulinum toxin type A (BoNT/A). Contractile responses to electric field stimulation (EFS), high K+ (60 mM) and ACh (100 microM) were evaluated 24 and 48 hours after antral intramuscular injection of BoNT/A or vehicle.RESULTS:
BoNT/A inhibited muscular contraction caused by high K+ and ACh. Contractile responses to low (1 & 4 Hz) and high (8 & 20 Hz) frequency EFS of antral muscle strips 24 and 48 hours after antral intramuscular injection of BoNT/A were significantly inhibited.CONCLUSION:
The ability of BoNT/A to directly inhibit antral muscular contractility suggests a new mechanism for the pharmacologic actions of BoNT-direct inhibition of muscular contraction.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Antre pylorique
/
Techniques in vitro
/
Toxines botuliniques
/
Acétylcholine
/
Guinée
/
Toxines botuliniques de type A
/
Actions pharmacologiques
/
Cochons d'Inde
/
Injections musculaires
/
Contraction musculaire
Limites du sujet:
Animaux
Pays comme sujet:
Afrique
langue:
Anglais
Texte intégral:
Yonsei Medical Journal
Année:
2012
Type:
Article
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