Selection of resistant fungi in liver transplant recipients during use of newer antifungal agents -- a report of two cases
Annals of the Academy of Medicine, Singapore
;
: 287-290, 2011.
Article
Dans Anglais
| WPRIM
| ID: wpr-229670
ABSTRACT
<p><b>INTRODUCTION</b>Because invasive fungal infections cause significant morbidity and mortality in liver transplant recipients, the use of antifungal prophylaxis, and the early empirical use of antifungal agents, is widespread on liver transplant units. The new-generation azoles such as voriconazole and the echinocandins have been welcome additions to the antifungal armamentarium. These agents have become the leading options for prophylaxis in liver transplant units, despite the absence of strong data for their efficacy in this setting.</p><p><b>CLINICAL PICTURE</b>We report two recipients of living-donor liver transplants who became infected/colonised with fungi resistant to an echinocandin and the azoles after exposure to these agents. One patient developed trichosporonosis while on caspofungin and the other became infected/ colonised with Candida glabrata that was resistant to voriconazole and posaconazole.</p><p><b>CONCLUSION</b>We report these to highlight some of the consequences of using the newer antifungal agents.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pyrimidines
/
Triazoles
/
Fluconazole
/
Transplantation hépatique
/
Issue fatale
/
Résistance des champignons aux médicaments
/
Utilisations thérapeutiques
/
Traitement médicamenteux
/
Allergie et immunologie
/
Échinocandines
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Annals of the Academy of Medicine, Singapore
Année:
2011
Type:
Article
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