Autoantibodies and autoimmunity in simian immunodeficiency virus-infected monkeys / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 379-383, 2007.
Article
Dans Chinois
| WPRIM
| ID: wpr-229970
ABSTRACT
<p><b>OBJECTIVE</b>To study the relationship between simian acquired immunodeficiency syndromn (SAIDS) and autoimmunity in simian immunodeficiency virus (SIV)-infected monkeys.</p><p><b>METHODS</b>Indirect immunofluorescence assays were performed to detect plasma or serum autoantibodies in SIV-infected monkeys. The heart, liver, spleen, lung, kidney, and lymph node of BALB/c mice, a strain of endothelial cell ECV304, and granulocytes were used as target antigens. These results were compared with HE stained slides of SIV-infected monkeys.</p><p><b>RESULTS</b>The levels of various autoantibodies, including anti-lymphocyte autoantibodies, anti-endothelial cell autoantibodies, and anti-granulocyte antibodies, increased after SIV infection in monkeys. Moreover, pathological examinations showed injuries in the lymphoid tissue and vascular pathological changes in cerebral cortex, submucosa of gastrointestinal tract, interstitial capillaries of myocardium, nephron of the kidney, and sinusoid cell of liver.</p><p><b>CONCLUSION</b>The increased autoantibodies and the pathological changes of tissues and organs confirm the existence of autoimmunity in SIV-infected monkeys.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Autoanticorps
/
Sang
/
Lymphocytes
/
Auto-immunité
/
Syndrome d'immunodéficience acquise du singe
/
Virus de l'immunodéficience simienne
/
Cellules endothéliales
/
Allergie et immunologie
/
Granulocytes
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Acta Academiae Medicinae Sinicae
Année:
2007
Type:
Article
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