Study on the genome structure of human telomeric repeat binding factor 1 and its pseudogenes / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 407-411, 2003.
Article
Dans Chinois
| WPRIM
| ID: wpr-231036
ABSTRACT
<p><b>OBJECTIVE</b>To determine the genome structure of human telomeric repeat binding factor 1 (TERF1) and its pseudogenes.</p><p><b>METHODS</b>Sequences were obtained from GenBank and analyzed using the BLAST program and other relevant biology program (Sequencher, DNA Strider and Autoassembler, etc) to determine the genome and pseudogenome structure of TERF1. PCR and sequencing were performed to verify the results.</p><p><b>RESULT</b>TERF1 gene which mapped to 8q13 was divided into 10 exons. It had four processed pseudogenes located on chromosome 13, 18, 21 and X respectively (Psi TERF1-13 Psi TERF1-18 Psi TERF1-21 and Psi TERF1-X ). They were entire intronless TERF1 genes which lacked some exons. Three homologous fragments of at least 60 kb on the flanking region of Psi TERF1-13, Psi TERF1-18 and Psi TERF1-21, respectively were noted.</p><p><b>CONCLUSION</b>TERF1 gene has 10 exons. It has four processed pseudogenes which are located on chromosome 13, 18, 21, and X, respectively. Large homologous fragments that belong to the recently duplicated segments are transchromosomal duplications.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pseudogènes
/
Cartographie chromosomique
/
Protéine-1 se liant aux répétitions télomériques
/
Structures génétiques
/
Génétique
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Journal of Zhejiang University. Medical sciences
Année:
2003
Type:
Article
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