Evaluation of serum interleukin-18 and interleukin-10 in patients with HIV-1 and hepatitis viruses co-infected subjects / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 94-96, 2003.
Article
Dans Chinois
| WPRIM
| ID: wpr-231112
ABSTRACT
<p><b>OBJECTIVE</b>To study the significance of cytokines in patients with HIV and hepatitis viruses co-infection.</p><p><b>METHODS</b>Serum levels of IL-18 and IL-10 were measured by enzyme-linked immunosorbent assay (ELISA). HIV-RNA levels were measured in EDTA plasma by quantitative reverse polymerase chain reaction (PCR). CD4(+) lymphocyte counts were determined by four-color Flow cytometry (FCM).</p><p><b>RESULTS</b>The levels of IL-18 were significantly higher in HIV-infected persons compared with those in controls (P<0.05). With HIV disease progression, IL-18 levels increased while Il-10 levels decreased. HCV patients showed lower levels of IL-18 and IL-10 than those of the co-infection group.</p><p><b>CONCLUSION</b>Univariate analyses shows significant co-variables IL-10 in co-infection. Up-regulating IL-18 activity and/or down-regulating IL-10 may be a potential therapy to patients with HIV and hepatitis viruses co-infection.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Sang
/
Lymphocytes T cytotoxiques
/
Syndrome d'immunodéficience acquise
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VIH-1 (Virus de l'Immunodéficience Humaine de type 1)
/
Interleukine-10
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Hépatite C
/
Lymphocytes auxiliaires Th2
/
Lymphocytes auxiliaires Th1
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Interleukine-18
/
Allergie et immunologie
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Journal of Zhejiang University. Medical sciences
Année:
2003
Type:
Article
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