Analysis of drug-resistant multi-loci mutation of P area of HBV genome in 32 patients with chronic hepatitis B / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 208-210, 2011.
Article
Dans Chinois
| WPRIM
| ID: wpr-231148
ABSTRACT
<p><b>OBJECTIVE</b>In order to deeply understand the effects of nucleoside analogues to HBV DNA polymerase area, which initiate a state of drug resistance due to HBV genome mutation.</p><p><b>METHODS</b>Using PCR product direct sequencing method to test the gene sequence of P area of HBV genome of the patients who taking nucleoside analogues and showing signs of virologic breakthrough.</p><p><b>RESULTS</b>More resistance mutations can be find in HBV DNA polymerase area, which causing clinically cross drug resistance and multiple resistance.</p><p><b>CONCLUSION</b>We should choose higher genetic barrier for the initial treatment. And the patients long-term using of nucleoside analogues, should be regularly monitored serum HBV DNA level, in order for early detection of virological breakthrough and timely intervention.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Virologie
/
Virus de l'hépatite B
/
Réaction de polymérisation en chaîne
/
Génome viral
/
Hépatite B chronique
/
Résistance virale aux médicaments
/
Génétique
/
Mutation
Type d'étude:
Étude de dépistage
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Experimental and Clinical Virology
Année:
2011
Type:
Article
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