Clinical value of CD64 expression in adults with measles complicating bacterial pneumonia / 中华实验和临床病毒学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the clinical value of expression of peripheral blood neutrophil CD64 in adults with measles complicating pneumonia.</p><p><b>METHODS</b>106 patients were divided into two groups by clinical manifestation and bacteria study measles complicating bacterial pneumonia group and measles complicating viral pneumonia, using flow cytometry determination of CD64, C-reactive protein (CRP) and white blood cell (WBC) count.</p><p><b>RESULTS</b>The expression of CD64 in the bacterial pneumonia group with eruptive stage was (32.15 +/- 11.07) MFI, which was significantly higher than that in the group of with recovery stage (10.6 +/- 3.23) MFI (P < 0.01) and viral pneumonia (9.55 +/- 3.48) MFI (P < 0.01). These markers were considered positive if CD64 > or = 8.5 MFI, CRP > or = 10 mg/L and WBC > or = 9.05 x 10(9)/L. Their sensitivity was 78.12%, 80.48% and 59.37%. Their specificity was 76.19% ,67.67% and 64.28%. Their accuracy rate was 77.35%, 74.52%, 61.32%; CD64 has a positive relationship with CRP.</p><p><b>CONCLUSION</b>Compared to CRP, expression of peripheral blood neutrophil CD64 can be a better marker in the early diagnosis of patients with measles complicating bacterial pneumonia and as one of the indicators of disease conditions.</p>