Regulatory roles of compound danshen in the downstream path of cyclooxygenases in rheumatoid arthritis patients' synovium / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 1416-1419, 2013.
Article
Dans Chinois
| WPRIM
| ID: wpr-231670
ABSTRACT
Rheumatoid arthritis (RA) belongs to Bi syndrome (arthralgia) in Chinese medicine. Till now there lacks effective therapeutic methods. Recently cyclooxygenases (COXs) inhibitors, having regulator roles for many pro-inflammatory cytokines, have been widely used in RA treatment. But due to existing cardiovascular risks, researches on targeting the downstream specific factors of COXs have been under discussion. Considering the key role of blood stasis syndrome (BSS) in the pathology of RA and the fact that thromboxane A2 (TXA2) plays a pivotal role in BSS, we theoretically explored possible regulatory roles of Compound Danshen, a representative therapy in blood activating stasis removing method in the downstream path of COXs in synovial cells of RA. We proposed a brand new research direction of RA researches.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacologie
/
Polyarthrite rhumatoïde
/
Membrane synoviale
/
Médicaments issus de plantes chinoises
/
Chimie
/
Prostaglandin-endoperoxide synthases
/
Salvia miltiorrhiza
/
Diagnostic
/
Médecine traditionnelle chinoise
/
Métabolisme
Type d'étude:
Etude diagnostique
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Chinese Journal of Integrated Traditional and Western Medicine
Année:
2013
Type:
Article
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