Clinical significance and relevant laboratory techniques of detecting azoospermia factors of the Y chromosome / 中华男科学杂志
National Journal of Andrology
;
(12): 1117-1120, 2007.
Article
Dans Chinois
| WPRIM
| ID: wpr-232000
ABSTRACT
Microdeletions of the Y chromosome are a most common known genetic cause of spermatogenetic failure in infertile men. Recent studies have revealed the existence of genetic factors in the long arm of the Y chromosome Yq11.23, known as azoospermia factors (AZF), which are further divided into three separate regions including AZFa, AZFb and AZFc. The AZF deletions are due to different recombination between large palindromic sequences during mesophase. Microdeletions of different AZF regions cause different degrees of spermatogenic impairment. The present paper reviews the clinical significance and relevant laboratory techniques of detecting AZF of the Y chromosome.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Aberrations des chromosomes sexuels
/
Délétion de segment de chromosome
/
Protéines du plasma séminal
/
Chromosomes Y humains
/
Diagnostic
/
Azoospermie
/
Locus génétiques
/
Génétique
/
Infertilité masculine
Type d'étude:
Etude diagnostique
Limites du sujet:
Humains
/
Mâle
langue:
Chinois
Texte intégral:
National Journal of Andrology
Année:
2007
Type:
Article
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