Two ways of constructing concealed penis model in rats: a comparative and analytical study / 中华男科学杂志
National Journal of Andrology
; (12): 879-882, 2007.
Article
de Zh
| WPRIM
| ID: wpr-232047
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To establish a stable rat experimental model of concealed penis for studying the effect of buried penis on the structure and function of the corpus cavernosum.</p><p><b>METHODS</b>Ninety male SD rats, aged 2 weeks, were randomly divided into 3 groups (A, B and C) of equal number. Groups A and B underwent surgery with intra-purse suture of the penile root and folding suture of the prepuce, respectively, to bury the penis, while Group C were included as sham operation controls.</p><p><b>RESULTS</b>In Group A, death resulted in 4 cases from acute post-operative urine retention, failure in burying the penis occurred in 5 cases because of soft tissue ulceration around the urethral orifice and in another 3 due to loose concealment. In Group B, 1 died from deep anesthesia and 2 from acute post-operative urine retention. With the penile development and erection, 7 in Group A and 10 in Group B protruded the penis in different stages. In Group C, 1 died from deep anesthesia. The operations succeeded in all the other rats in Groups A and B, with the success rates of 36.7% and 56.7%, respectively. And the concealment could be relieved any time during the experiment.</p><p><b>CONCLUSION</b>The experimental rat model of concealed penis can be successfully established by both intra-purse suture of the penile root and folding suture of the prepuce, which is stable and similar to the natural course of this disorder in human.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pénis
/
Chirurgie générale
/
Malformations
/
Malformations urogénitales
/
Répartition aléatoire
/
Rat Sprague-Dawley
/
Modèles animaux de maladie humaine
Type d'étude:
Clinical_trials
Limites du sujet:
Animals
/
Humans
/
Male
langue:
Zh
Texte intégral:
National Journal of Andrology
Année:
2007
Type:
Article