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A study of interleukin-10 gene polymorphisms in Miao, Dong and Buyi ethnics of Guizhou / 中华医学遗传学杂志
Chinese Journal of Medical Genetics ; (6): 116-120, 2013.
Article Dans Chinois | WPRIM | ID: wpr-232191
ABSTRACT
<p><b>OBJECTIVE</b>To investigate allelic frequencies of interluekin-10 (IL-10) gene promoter in Miao, Dong and Buyi ethnics of Guizhou.</p><p><b>METHODS</b>TaqMan MGB-based real-time PCR was used to determine the genotypes of IL-10 -819 and IL-10 -592 in 589 Miao, Dong and Buyi ethnics of Guizhou.</p><p><b>RESULTS</b>The allelic frequency of IL-10 -819 in Miao ethnics was significantly different from those in Dong or Buyi ethnics. Allelic frequencies of IL-10 -592 in Miao ethnics was significantly different from those in Dong or Buyi ethnics. In Miao, Dong and Buyi ethnics, the distributions of genotype frequencies of IL-10 -819 and IL-10 -592 were statistically different from Han ethnics from Guizhou and Taiwan of China as well as South Koreans.</p><p><b>CONCLUSION</b>There is a heterogeneity in the frequencies of polymorphisms of IL-10 promoter among different ethnic groups.</p>
Sujets)
Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Chine / Régions promotrices (génétique) / Interleukine-10 / Polymorphisme de nucléotide simple / Groupes de population / Asiatiques / Allèles / Ethnologie / Fréquence d&apos;allèle / Génétique Limites du sujet: Humains Pays comme sujet: Asie langue: Chinois Texte intégral: Chinese Journal of Medical Genetics Année: 2013 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Chine / Régions promotrices (génétique) / Interleukine-10 / Polymorphisme de nucléotide simple / Groupes de population / Asiatiques / Allèles / Ethnologie / Fréquence d&apos;allèle / Génétique Limites du sujet: Humains Pays comme sujet: Asie langue: Chinois Texte intégral: Chinese Journal of Medical Genetics Année: 2013 Type: Article