Interruption failure of heptitis B virus vaccination in mother-to-infant transmission and heptitis B virus genotypes and preC/BCP mutations / 中华流行病学杂志
Chinese Journal of Epidemiology
;
(12): 331-333, 2007.
Article
Dans Chinois
| WPRIM
| ID: wpr-232310
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association of heptitis B virus (HBV) genotypes and precore(PreC)/basal core promoter(BCP) mutation with interruption failure of HBV vaccination in mother-to-infant transmission.</p><p><b>METHODS</b>A total number of 208 serum samples were collected from infants and mothers,including 16 infants who had become HBsAg-positive despite a complete and timely course of immunization and another 88 infants successfully protected from mother-to infant HBV transmission. HBV genotypes were determined by type-specific primers PCR method. PreC/BCP mutations were detected by direct sequencing of PCR products, and Clustal W 1.8 software was applied to analyzing the sequences.</p><p><b>RESULTS</b>Of 16 mothers who were having vaccine failure infants, 15 (93.8%) were HBeAg positive and infected with genotype C (15/15, 100%). Among 88 mothers of having children being protected by vaccine, 51 (58.0%) were HBeAg positive, with 45.1% (23/51) of genotype C. The proportion of genotype C in HBeAg mothers of infants with vaccine failure, was significantly higher than that of mothers with vaccine protected infants (chi2 = 14.3, P = 0.003). However, the frequencies of T1762/A1764 mutations had no significant differences between genotype C HBeAg positive mothers with vaccine failure or protected infants (33.3% and 13.3%, respectively, P = 0.4). No A1896 mutation was found in these two groups.</p><p><b>CONCLUSION</b>HBV genotype C might contribute to the immune failure of HBV vaccination in mother-to-infant transmission, while PreC/BCP mutation might not have correlation with it.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Complications infectieuses de la grossesse
/
Virologie
/
Virus de l'hépatite B
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Réaction de polymérisation en chaîne
/
Régions promotrices (génétique)
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Vaccins anti-hépatite B
/
Transmission verticale de maladie infectieuse
/
Allergie et immunologie
/
Gènes viraux
/
Génétique
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Nouveau-né
/
Grossesse
langue:
Chinois
Texte intégral:
Chinese Journal of Epidemiology
Année:
2007
Type:
Article
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