Advances in the chemical and biological studies of polyamides / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1089-1093, 2008.
Article
Dans Chinois
| WPRIM
| ID: wpr-232638
ABSTRACT
Polyamides, containing N-methylpyrrole (Py) and N-methyl-imidazole (Im) amino acids, are synthetic oligomers programmed to read the DNA double helix in the minor groove with high affinities and sequence specificities resulting in modulation of gene expression. They are cell permeable, stable and have no cytotoxicity, which provide a promising tool of gene regulation. We describe here recent advances in the field of DNA binding polyamides, including pairing rules, specifities and affinities to DNA, synthesis methods, cellular and nuclear uptake properties, gene regulation and effectiveness in vivo. The potential problems and difficulties in future research are also discussed.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacologie
/
Pyrroles
/
ADN
/
Chimie
/
Régulation de l'expression des gènes
/
Prise d'empreintes sur l'ADN
/
Appariement de bases
/
Génétique
/
Imidazoles
/
Métabolisme
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2008
Type:
Article
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