Advances in the study of small peptides in targeted drug delivery system / 药学学报
Acta Pharmaceutica Sinica
;
(12): 992-996, 2008.
Article
Dans Chinois
| WPRIM
| ID: wpr-232654
ABSTRACT
Recently various peptide receptors which displayed the highest binding affinity and specificity with their peptide ligands by ligand-receptor have been exploited to develop drug delivery system which can directionally deliver drug to targeted cell. It is significant to study and applicate, including targeted drug delivery system mediated by bombesin receptor, somatostatin receptor, SynB3 receptor, LH-RH receptor and other peptide receptor, et al. Several small peptide fragments were selected as carriers radicals combining doxorubicin, 2-pyrrolino-DOX, methotrexate, cis-platinum, and camptothecin to form hybrid cytotoxic analogs. These highly potent cytotoxic analogs have been designed as targeted anti-tumor agents for the treatment and study of various cancers that possess receptors for the carrier peptide.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Oligopeptides
/
Pyrroles
/
Doxorubicine
/
Systèmes de délivrance de médicaments
/
Récepteur somatostatine
/
Récepteur bombésine
/
Récepteurs à la gonadolibérine
/
Utilisations thérapeutiques
/
Traitement médicamenteux
/
Métabolisme
Limites du sujet:
Animaux
/
Humains
langue:
Chinois
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2008
Type:
Article
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