Absorption dynamic characteristics of clopidogrel bisulfate polymorphs in rat / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1268-1272, 2011.
Article
Dans Chinois
| WPRIM
| ID: wpr-232999
ABSTRACT
Four crystalline forms of clopidogrel bisulfate were characterized by analytical techniques. Aiming to research the absorption characteristics of clopidogrel bisulfate polymorphs after taken orally by rat, and to estimate the influence of crystal form to pharmacodynamic action, four crystalline forms of clopidogrel bisulfate were administered intragastrically to rats, and high performance liquid chromatography (HPLC) was used to measure the contents of clopidogrel bisulfate and its metabolite in rat plasma. The metabolite of clopidogrel bisulfate was detected in rat plasma. There were significant deviations among four crystalline forms in the areas under curve of the metabolite of clopidogrel bisulfate. We concluded that the different crystal forms of clopidogrel bisulfate showed different pharmacokinetic characteristics, which might affect pharmacodynamic action.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Spectrophotométrie IR
/
Diffraction des rayons X
/
Sang
/
Ticlopidine
/
Calorimétrie différentielle à balayage
/
Pharmacocinétique
/
Antiagrégants plaquettaires
/
Répartition aléatoire
/
Chimie
/
Administration par voie orale
Type d'étude:
Étude pronostique
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2011
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS