Diterpene constituents of Tripterygium willfordii (II) / 药学学报
Acta Pharmaceutica Sinica
;
(12): 942-945, 2011.
Article
Dans Chinois
| WPRIM
| ID: wpr-233072
ABSTRACT
In order to study the constituents and pharmacology of Tripterygium plants (Tripterygium willfordii Hook.f), a variety of chromatography methods were used. Four compounds were isolated from Tripterygium plant and their structures were elucidated by UV, IR, MS, HR-MS, 1H NMR, 13C NMR and 2D-NMR techniques. The isolated compounds were named as triptonide (1), neo-triptetraolide (2), 2alpha-hydroxytriptonide (3), and 15-hydroxytriptonide (4), separately. Compounds 3, 4 belong to new diterpenoids, which can inhibit the growth of K562 cells (leukemia cells) and HL60 cells (acute myeloid leukemia cells).
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacologie
/
Plantes médicinales
/
Triterpènes
/
Médicaments issus de plantes chinoises
/
Structure moléculaire
/
Chimie
/
Racines de plante
/
Cellules HL-60
/
Cellules K562
/
Tripterygium
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2011
Type:
Article
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