Role of B-cell-activating-factor in immune regulation--review / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 631-634, 2006.
Article
Dans Chinois
| WPRIM
| ID: wpr-233529
ABSTRACT
B cell activating factor (BAFF) is one of the TNF family member, regulates the survival and maturation of B lymphocyte. BAFF binds to three receptors BCMA, TACI and BAFF-R. In recent years, studies have revealed important roles of BAFF and its receptors in immune regulation of antibody isotype switching, germinal center maintenance, and T cell co-stimulation, that may provide new drugs in the future for the treatment of autoimmune disorders, lymphoma and B cell immunodeficiencies. Therefore, the structure, expression, receptors, biological function and clinical application of BAFF are briefly summarized in this review.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Lymphocytes B
/
Allergie et immunologie
/
Facteur d'activation des lymphocytes B
/
Récepteur du BAFF
/
Antigène de maturation des cellules B
/
Protéine TACI
/
Immunité
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Journal of Experimental Hematology
Année:
2006
Type:
Article
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