Effect of the drug-resistant attenuated Bacillus proteus on CD80 and CD86 protein expression in peripheral blood dendritic cells of hepatitis B patients / 南方医科大学学报
Journal of Southern Medical University
; (12): 801-803, 2009.
Article
de Zh
| WPRIM
| ID: wpr-233679
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the effect of the drug-resistant attenuated Bacillus proteus on the protein expression of CD80 and CD86 in peripheral blood dendritic cells (DCs) of hepatitis B patients.</p><p><b>METHOD</b>Peripheral blood monocytes were isolated from HBV-infected patients and the DCs were separated and induced to differentiate in vitro. The expression of CD80 and CD86 proteins on cultured DCs were examined using flow cytometry.</p><p><b>RESULTS</b>The expression rate of CD80 and CD86 of chronic hepatitis B patients increased significantly (P=0.000), while the positive expression rate of CD80 and CD86 showed no obvious variation in healthy individuals (P=0.185 and P=0.118, respectively).</p><p><b>CONCLUSIONS</b>Bacillus proteus can significantly increase CD80- and CD86-positive cell percentage in peripheral blood DCs of HBV-infected patients, but has no such an effect in healthy individuals.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Bacillus
/
Cellules dendritiques
/
Vaccins atténués
/
Études cas-témoins
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Régulation de l'expression des gènes
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Antigène CD80
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Résistance bactérienne aux médicaments
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Allergie et immunologie
/
Antigène CD86
/
Hépatite B
Type d'étude:
Observational_studies
Limites du sujet:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
langue:
Zh
Texte intégral:
Journal of Southern Medical University
Année:
2009
Type:
Article