The nucleus origin of acoustically evoked short latency negative response in guinea pigs / 中华耳鼻咽喉头颈外科杂志
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
;
(12): 848-853, 2014.
Article
Dans Chinois
| WPRIM
| ID: wpr-233785
ABSTRACT
<p><b>OBJECTIVE</b>This study established a model of acoustically evoked short latency negative response (ASNR) in guinea pigs. Stereotaxic coordinate guided electrolytic lesion was applied to animal brainstem nuclei, the vestibular nucleus and the cochlear nucleus, to define the neural origin of ASNR.</p><p><b>METHODS</b>Twenty four guinea pigs with normal hearing were randomly divided into the control group (8 subjects, 16 ears) and the deafened group (16 subjects, 32 ears). Each animal experienced the auditory brainstem response (ABR) test. According to the presence of ASNR, the deafened group was further divided into ASNR group and non-ASNR group. Electrolytic lesion was conducted to the vestibular nucleus and cochlear nucleus respectively, followed by ABR test. The lesion structures were verified by brainstem slice and microscope.</p><p><b>RESULTS</b>In deafened group, the ASNR was elicited in 10 ears (31.3%). The ASNR was eliminated due to the electrolytic destruction to the vestibular nucleus, but it remained unchanged after the same procedure to the cochlear nucleus.</p><p><b>CONCLUSION</b>It is clear that the ASNR is originated from the vestibular nucleus, but not the cochlear nucleus.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Temps de réaction
/
Acoustique
/
Noyaux vestibulaires
/
Saccule et utricule
/
Potentiels évoqués auditifs du tronc cérébral
/
Noyau cochléaire
/
Cochons d'Inde
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
Année:
2014
Type:
Article
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