Expression and activity of membrane surface tissue factor in peripheral blood cells of patients with cerebral infarction / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1376-1378, 2008.
Article
Dans Chinois
| WPRIM
| ID: wpr-234230
ABSTRACT
This study was aimed to investigate the expression and activity of membrane surface tissue factor (TF) of monocytes and platelets in peripheral blood cells from patients with cerebral infarction and their clinical significance. The TF expressions in monocytes and platelets from 25 patients with cerebral infarction were detected by flow cytometry, the TF activity was detected by chromogenic reaction method, and compared with 24 normal people used as control. The results showed that the TF expressions of monocytes and platelets in peripheral blood cells from patients with cerebral infarction were significantly higher than that in normal controls (p<0.01), and TF activity was also higher in patients than that in controls (p<0.01). In conclusion, the expression and activity of membrane surface in patients with cerebral infarction were enhanced, the hematocyte-derived tissue factor as a trigger in coagulation pathway is involved in pathological thrombosis in patients with cerebral infarction.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Sang
/
Cellules sanguines
/
Thromboplastine
/
Monocytes
/
Études cas-témoins
/
Infarctus cérébral
/
Membrane érythrocytaire
/
Cytométrie en flux
/
Métabolisme
Type d'étude:
Étude observationnelle
Limites du sujet:
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Journal of Experimental Hematology
Année:
2008
Type:
Article
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