Association of the polymorphism of synaptobrevins/vesicle-associated membrane proteins 8 gene with coronary heart disease in Chinese Han population / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 329-332, 2010.
Article
Dans Chinois
| WPRIM
| ID: wpr-234408
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association of synaptobrevins/vesicle-associated membrane proteins 8 (VAMP8) gene rs1010 polymorphism with coronary heart disease (CHD) in Chinese Han population.</p><p><b>METHODS</b>The allele and genotype frequencies of the VAMP8 gene rs1010 locus in 185 CHD patients and 149 controls were analyzed by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing.</p><p><b>RESULTS</b>There was polymorphism of the VAMP8 gene rs1010 locus in the studied population. The distribution of VAMP8 genotypes was in Hardy-Weinberg equilibrium. The frequency of the A allele in the CHD group was significantly higher than that in control (67.3% vs 53.0%, P< 0.05). Multiple logistic regression analysis showed that genotypes AA and AG were independent risk factors of coronary heart disease. The odds ratio (OR) of (AA+AG) genotype versus GG genotype was 1.969,95% CI 1.032-3.755.</p><p><b>CONCLUSION</b>The VAMP8 rs1010 polymorphism was associated with CHD risk in Chinese Han population, the A allele might serve as a genetic risk factor of coronary heart disease.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Polymorphisme génétique
/
Polymorphisme de restriction
/
Réaction de polymérisation en chaîne
/
Maladie coronarienne
/
Prédisposition génétique à une maladie
/
Asiatiques
/
Protéines R-SNARE
/
Génétique
/
Génotype
Type d'étude:
Facteurs de risque
Limites du sujet:
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Medical Genetics
Année:
2010
Type:
Article
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