Characteristics of JC virus VLP-Z for targeting gene delivery / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 572-576, 2013.
Article
Dans Chinois
| WPRIM
| ID: wpr-234609
ABSTRACT
The characteristics of virus-like particle (VLP) of JC virus (JCV) as a vector for targeting gene delivery was determined. The exogenous DNA (PUC19) packaged in VLP-Z was resistant to DNase I. VLP-Z was able to deliver a reporter plasmid pEGFP-N1 into HeLa cells and the green fluorescent reporter protein was expressed in these cells. VLP-Z was also able to bind IgG by interaction with the Z fragment of VLP-Z and IgG. These results suggested that VLP-Z might be used as a vector to deliver therapeutic genes to target cells with incorporating IgG antibodies.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Virion
/
Immunoglobuline G
/
Cellules HeLa
/
Thérapie génétique
/
Techniques de transfert de gènes
/
Virus JC
/
Ciblage de gène
/
Vecteurs génétiques
/
Génétique
/
Métabolisme
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Journal of Biomedical Engineering
Année:
2013
Type:
Article
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