Expressions of OCT4 and CD133 and their correlation in colonic cancer / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the expressions of Oct4 and CD133 and their correlation in colonic cancer.</p><p><b>METHODS</b>The expression of Oct4 and CD133 were detected by immunohistochemistry in 30 colon cancer specimens and the paired adjacent tissues.</p><p><b>RESULTS</b>The positivity rates of Oct4 and CD133 expression were 83.3% (25/30) and 73.3% (22/30) in colonic cancer tissue, respectively, and their expressions were positively correlated (r=0.586, P<0.05). The matched adjacent tissues showed significantly lower levels of Oct4 and CD133 expressions (P<0.01).</p><p><b>CONCLUSION</b>The expressions of Oct4 and CD133 are upregulated in colonic cancer compared with those in the adjacent tissues and show a positive correlation. Oct4 and CD133 may play an important role in the development of colon cancer.</p>