Studies on protective effects of Niuhuang Shangqing pills on cerebral ischemia / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 943-948, 2007.
Article
Dans Chinois
| WPRIM
| ID: wpr-235284
ABSTRACT
<p><b>OBJECTIVE</b>To discuss the protective effect of Niuhuang Shangqing pills (NSP) on the experimental cerebral ischemia and the influence of blood rheology in animals.</p><p><b>METHOD</b>Using the middle cerebral artery occlusion (MCAO), bilateral common carotid artery ligation and lipopolysaccharide (LPS) in combination with carrogeenin (Ca)-induced stagnation of blood model rats, we investigated the influence of NSP on the physical sign indexes, brain infarct size and the water content, the content of lactate(LD), glutathione peroxidase (GPx), catalase (CAT), malondialdehyde (MDA) and the blood rheology.</p><p><b>RESULT</b>The 3.00, 1.50 g x kg(-1) dosage groups of NSP decreased the neurosigns indexes, significantly reduced the brain infarct areas in MCAO rats, decreased the brain water content, increased the activities of GPx and CAT, decreased the content of LD and MDA in bilateral common carotid artery ligation rats. They improved the blood rheology in lipopolysaccharide (LPS) in combination with carrogeenin (Ca)-induced stagnation of blood model rats.</p><p><b>CONCLUSION</b>NSP has the function of protective effect on experimental experimental cerebral ischemia.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Pharmacologie
/
Plantes médicinales
/
Sang
/
Viscosité sanguine
/
Encéphale
/
Médicaments issus de plantes chinoises
/
Catalase
/
Répartition aléatoire
/
Encéphalopathie ischémique
Type d'étude:
Etude diagnostique
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
China Journal of Chinese Materia Medica
Année:
2007
Type:
Article
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