Association of catalase genotype with oxidative stress in the predication of colorectal cancer: modification by epidemiological factors / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 156-162, 2012.
Article
Dans Anglais
| WPRIM
| ID: wpr-235541
ABSTRACT
<p><b>OBJECTIVE</b>This paper aims to assess the interaction between common variations in catalase (CAT) polymorphic gene and environmental factors for antioxidant defense enzyme in modulating individual susceptibility to colorectal cancer (CRC).</p><p><b>METHODS</b>A case-control study with 880 colorectal cancer cases and 848 controls was conducted to investigate whether variations in the catalase (CAT) gene, one of the genes involved in scavenging oxidative stress, influenced susceptibility to CRC.</p><p><b>RESULTS</b>The interaction between life style and genotypes as well as with their effects on colorectal cancer was deduced from the present study. Significant difference (P = 0.01) was identified in the distribution of CAT genotype between the colorectal cancer cases and the controls. The CRC cases had significantly lower mean activity than the controls (P < 0.01). Correlation analyses revealed statistically significant correlations between CAT activity and CAT genotype (P < 0.01).</p><p><b>CONCLUSION</b>The risk of CRC was associated with smoking, low vegetable consumption, high pork and poultry consumptions, and low or high BMI. This is the first study reporting an association of polymorphism CAT-21A > T with colorectal cancer. Low CAT activity was associated with an increased risk of CRC; however, no evidence was found to support an association between CAT-21A > T polymorphism and CRC risk.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Tumeurs colorectales
/
Catalase
/
Études cas-témoins
/
Réaction de polymérisation en chaîne
/
Épidémiologie
/
Stress oxydatif
/
Génétique
/
Génotype
/
Métabolisme
Type d'étude:
Étude observationnelle
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Biomedical and Environmental Sciences
Année:
2012
Type:
Article
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