Liver enzymes concentrations are closely related to prediabetes: findings of the Shanghai Diabetes Study II (SHDS II) / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 30-37, 2012.
Article
Dans Anglais
| WPRIM
| ID: wpr-235574
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship of liver enzymes with hyperglycemia in a large population in Shanghai and identify the association between liver enzymes and insulin resistance.</p><p><b>METHODS</b>A total of 3 756 participants were enrolled. Each participant underwent an oral glucose tolerance test and completed a questionnaire. Anthropometric indices were recorded and serum samples were collected for measurement.</p><p><b>RESULTS</b>Liver enzymes concentrations were independently associated with i-IGT, IFG+IGT, and diabetes. With the increase of ALT and GGT concentrations, ORs for i-IGT, IFG+IGT, and diabetes increased gradually. By comparing patients in the highest quartile of GGT concentrations or ALT concentrations with those in the lowest quartile (Q1), ORs for i-IGT, IFG+IGT, or diabetes was significant after adjustment. Both ALT and GGT concentrations were linearly correlated with HOMA-IR and independently associated with HOMA-IR [ALT OR (95% CI) 2.56 (1.51-4.34) P=0.00; GGT OR (95% CI) 2.66 (1.53-4.65) P=0.00].</p><p><b>CONCLUSION</b>Serum ALT and GGT concentrations were closely related to pre-diabetes and diabetes in the Shanghai population and positively associated with insulin resistance.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
État prédiabétique
/
Sang
/
Hémoglobine glyquée
/
Chine
/
Anthropométrie
/
Alanine transaminase
/
Métabolisme lipidique
/
Gamma-Glutamyltransferase
/
Foie
/
Métabolisme
Type d'étude:
Étude pronostique
Limites du sujet:
Adolescent
/
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
Pays comme sujet:
Asie
langue:
Anglais
Texte intégral:
Biomedical and Environmental Sciences
Année:
2012
Type:
Article
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