Salicylic acid derivatives as simplified and novel GK small molecule activators / 药学学报
Acta Pharmaceutica Sinica
;
(12): 514-520, 2013.
Article
Dans Chinois
| WPRIM
| ID: wpr-235635
ABSTRACT
Glucokinase (GK) is a new target for the treatment of type II diabetes mellitus (T2DM). In order to find a structure-simplified small molecule GK activator, 19 salicylic acid derivatives were designed and synthesized based on new lead compound (1). Experimental results showed that the potency of compound 8h is superior to control RO-28-0450 in GK activation.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacologie
/
Thiazoles
/
Conception de médicament
/
Structure moléculaire
/
Chimie
/
Salicylates
/
Activateurs d'enzymes
/
Activation enzymatique
/
Glucokinase
/
Hypoglycémiants
langue:
Chinois
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2013
Type:
Article
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