Changes in T cell subsets in children with sepsis, and their clinical significance / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 216-218, 2013.
Article
Dans Chinois
| WPRIM
| ID: wpr-236835
ABSTRACT
<p><b>OBJECTIVE</b>To observe changes in T cell subsets in children with sepsis and their prognosis, and to investigate the clinical significance of these changes in the occurrence and development of sepsis.</p><p><b>METHODS</b>Fifty children with severe sepsis and 150 children with general sepsis were enrolled as subjects, and 50 age-matched healthy children were included as controls. The percentages of CD3(+), CD4(+) and CD8(+) T cells in peripheral blood and CD4(+)/CD8(+) ratio were measured by flow cytometry. The pediatric critical illness score (PCIS) was calculated within 24 hours of admission.</p><p><b>RESULTS</b>The children with severe sepsis showed significantly lower percentages of CD3(+), CD4(+) and CD8(+) T cells CD4(+)/CD8(+) ratio and PCIS than the controls and children with general sepsis (P<0.01). Among the 200 cases of sepsis, the percentages of CD3(+), CD4(+) and CD8(+) T cells, CD4(+)/CD8(+) ratio and PCIS were significantly lower in the cured group than in the deceased group.</p><p><b>CONCLUSIONS</b>Children with sepsis have different degrees of cellular immunosuppression, and the degree of cellular immunosuppression is significantly correlated with the severity of the disease. Detection of T cell subsets in peripheral blood is of great significance for evaluating immune function and judging disease severity in children with sepsis.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pronostic
/
Sous-populations de lymphocytes T
/
Rapport CD4-CD8
/
Sepsie
/
Allergie et immunologie
Type d'étude:
Étude pronostique
Limites du sujet:
Enfant d'âge préscolaire
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Contemporary Pediatrics
Année:
2013
Type:
Article
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