Association between genetic polymorphisms in folate metabolic enzyme genes and colorectal cancer: a nested case-control study / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 429-432, 2006.
Article
Dans Chinois
| WPRIM
| ID: wpr-236924
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the interrelationship of genetic polymorphisms in folate metabolic enzymes (MTHFRC677T, MTHFRA1298C, MTRA2756G and MTRRA66G) and their combinative effects with colorectal cancer (CRC).</p><p><b>METHODS</b>A nested case-control study was designed and carried out. 140 CRC patients and 343 control subjects were included in this study. Polymorphisms of folate metabolic enzyme genes were genotyped by PCR-restriction fragment length polymorphism method. Risk of CRC was estimated by unconditional logistic model, and P value for interaction was calculated by likelihood test.</p><p><b>RESULTS</b>The allele of MTR2756G showed a positive association with CRC (OR = 2.04, 95% CI = 1.22 - 3.40). Those with MTHFR1298AA and MTR 2756AG/GG genotypes had an elevated risk with CRC (OR = 2.57, 95% CI, 1.42 -4.65), and their combinative effect showed a significant association with CRC (P = 0.04).</p><p><b>CONCLUSION</b>MTR2756G allele may be a risk factor of CRC, and interaction may exsit between polymorphisms of MTHFRA1298C and MTRA2756G. Further studies with larger sample and in different ethnic groups are needed.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Polymorphisme génétique
/
5-Methyltetrahydrofolate-homocysteine s-methyltransferase
/
Polymorphisme de restriction
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Tumeurs colorectales
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Études cas-témoins
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Odds ratio
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Réaction de polymérisation en chaîne
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Prédisposition génétique à une maladie
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Methylenetetrahydrofolate reductase (NADPH2)
/
Allèles
Type d'étude:
Etude d'étiologie
/
Étude observationnelle
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Oncology
Année:
2006
Type:
Article
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