Analysis of CYP17A1 gene mutation in a child patient with 17 alpha-hydroxylase/17, 20-lyase deficiency / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 439-442, 2013.
Article
Dans Chinois
| WPRIM
| ID: wpr-237231
ABSTRACT
<p><b>OBJECTIVE</b>To analyze CYP17A1 gene mutations in a child patient with 17 alpha-hydroxylase/17, 20-lyase deficiency (17OHD), and to review characteristics of CYP17A1 gene mutations in Chinese patients with 17OHD.</p><p><b>METHODS</b>Clinical data were collected. PCR and DNA sequencing were performed to detect mutations in the patient.</p><p><b>RESULTS</b>The patient has presented classical features of 17OHD including hypertension, hypokalemia, decreased sex hormones and plasma cortisol, and elevated blood adrenocorticotrophic hormone. A compound heterozygous mutation c.987C>A and c.985del was detected in the CYP17A1 gene, which resulted in two premature stop codons at positions 328 and 417.</p><p><b>CONCLUSION</b>A compound mutation, c.987C>A and c.985del, has been identified in a patient with 17OHD. Among CYP17A1 gene mutations identified in Chinese patients, missence mutations have been most common, and exons 5 and 8 have been the mutation hotspots.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Données de séquences moléculaires
/
Séquence nucléotidique
/
Steroid 17-alpha-hydroxylase
/
Hyperplasie congénitale des surrénales
/
Génétique
/
Lyases
/
Mutation
Type d'étude:
Étude pronostique
Limites du sujet:
Adolescent
/
Femelle
/
Humains
langue:
Chinois
Texte intégral:
Chinese Journal of Medical Genetics
Année:
2013
Type:
Article
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